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The new system consists primarily of a specially
designed flask with two inlets, one for gas (air)
supply and one for medium supply. There is also a combined outlet port on the side of the flask for the exhaust gas and the fermentation broth. The circular motion of the fermenter on a shaker,causes the fermentation broth to reach the outlet port and leave the glass flask. The small scale and simple handling makes it possible to operate many shaking bioreactor vessels simultaneously.
Publication:
Akgün A, Maier B, Preis D, Roth B, Klingelhöfer R, Büchs J, A Novel Parallel Shaken Bioreactor System for Continuous Operation, Biotechnol. Prog. 2004, 20, 1718-1724
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+ low investment costs
+ at least 6 parallel reactors
+ small liquid volume (tracer
experiments)
+ six equilibrium states at one
time
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